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TNG260

CAT: 0013-GTR19212036-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19212036-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNG260 is a selective CoREST deacetylase (CoreDAC) inhibitor that potently targets HDAC1 over HDAC3. It reverses STK11 loss-mediated anti-PD1 resistance by modulating the tumor immune microenvironment, reducing neutrophil infiltration and promoting immune-mediated tumor cell killing in preclinical studies.
CAS Number
2935964-98-8
Field of Research
Epigenetics & Chromatin, Molecular Biology
Purity
99.78% (May vary between batches)
Smiles
O=C (C1=CC=C (C=C1) S (C) (=N) =O) NC2=C (N) C=CC (C3=CC=C (C=C3) F) =C2
Molecular Formula
C20H18FN3O2S
Molecular Weight
383.44
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(R)-N-(4-Amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-4-(S-methylsulfonimidoyl)benzamide
CAS Number2935964-98-8
PubChem CID168264922
IUPAC NameN-[2-amino-5-(4-fluorophenyl)phenyl]-4-(methylsulfonimidoyl)benzamide
Molecular FormulaC20H18FN3O2S
Molecular Weight383.4
XLogP4.3
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity621
SMILES
C[S@@](=N)(=O)C1=CC=C(C=C1)C(=O)NC2=C(C=CC(=C2)C3=CC=C(C=C3)F)N
InChI
InChI=1S/C20H18FN3O2S/c1-27(23,26)17-9-4-14(5-10-17)20(25)24-19-12-15(6-11-18(19)22)13-2-7-16(21)8-3-13/h2-12,23H,22H2,1H3,(H,24,25)/t27-/m1/s1
InChIKey
JPFMYSJUFUEHBI-HHHXNRCGSA-N
Chemical Structure
2D Structure
2D structure of (R)-N-(4-Amino-4'-fluoro-[1,1'-biphenyl]-3-yl)-4-(S-methylsulfonimidoyl)benzamide
CAS: 2935964-98-8
CID: 168264922
Formula: C20H18FN3O2S
MW: 383.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight383.4
XLogP34.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass383.11037616
Monoisotopic Mass383.11037616
Topological Polar Surface Area104 Ų
Heavy Atom Count27
Formal Charge0
Complexity621
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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