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(S) -TNG260

CAT: 0804-HY-153358A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153358A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(S) -TNG260 is an isomer of TNG260. TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 causes HDAC1 inhibition and reverses anti-PD1 resistance driven by STK11 deletion. TNG260 reduces intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.
CAS Number
2935964-93-3
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-tng260.html
Purity
98.84
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC1=CC=C(C2=CC=C(F)C=C2)C=C1NC(C3=CC=C([S@@](=O)(C)=N)C=C3)=O
Molecular Formula
C20H18FN3O2S
Molecular Weight
383.44
References & Citations
[1]Ahronian L, et al. TNG260, a CoREST-selective deacetylase inhibitor, reverses anti-PD1 resistance driven by loss of STK11[J]. J Immunother, 2022, 10 (2) : A1-A1595.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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