K-Ras G12C-IN-3

K-Ras G12C-IN-3

• CAS Number: 1629268-19-4
• UNSPSC Description: K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C. IC50 value: Target: K-ras G12C inhibitor For more information, please see the following patent. Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers, and preparation thereof By Ren, Pingda; Liu, Yi; Li, Liansheng; Feng, Jun; Wu, Tao From PCT Int. Appl. (2014), WO 2014152588 A1 20140925.
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/K-Ras-G12C-IN-3.html
• Purity: 99.94
• Solubility: DMSO : ≥ 30 mg/mL
• Smiles: ClC(C=C(OC)C(C(N1CCN(C(C=C)=O)CC1)=O)=C2)=C2C3=CC(Cl)=CC=C3Cl
• Molecular Weight: 453.75
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported