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T025

CAT: 0013-GTR19204697-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204697-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
T025 is a potent pan-CLK inhibitor exhibiting low nanomolar affinity for CLK1-4. It demonstrates anti-proliferative activity in various cancer cell lines and is a useful research tool for investigating MYC-driven pathologies, including in studies of hematological and solid tumor models.
CAS Number
2407433-00-3
Product Name Alternative
CLK3, CLK1, CLK2, CLK4, T025, T-025, T 025
Field of Research
Cell Biology, Signal Transduction
Purity
98.08% (May vary between batches)
Solubility
DMSO:10 mg/mL (26.15 mM)
Smiles
CNc1nc (NCc2ncccn2) c2c (c[nH]c2n1) -c1ccc2ncccc2c1
Molecular Formula
C21H18N8
Molecular Weight
382.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine
CAS Number2407433-00-3
PubChem CID133082038
IUPAC Name2-N-methyl-4-N-(pyrimidin-2-ylmethyl)-5-quinolin-6-yl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Molecular FormulaC21H18N8
Molecular Weight382.4
XLogP3
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count29
Formal Charge0
Complexity527
SMILES
CNC1=NC2=C(C(=CN2)C3=CC4=C(C=C3)N=CC=C4)C(=N1)NCC5=NC=CC=N5
InChI
InChI=1S/C21H18N8/c1-22-21-28-19-18(20(29-21)27-12-17-24-8-3-9-25-17)15(11-26-19)13-5-6-16-14(10-13)4-2-7-23-16/h2-11H,12H2,1H3,(H3,22,26,27,28,29)
InChIKey
PMWVYONICYRLNY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine
CAS: 2407433-00-3
CID: 133082038
Formula: C21H18N8
MW: 382.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight382.4
XLogP33
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass382.16544261
Monoisotopic Mass382.16544261
Topological Polar Surface Area104 Ų
Heavy Atom Count29
Formal Charge0
Complexity527
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
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