T025

CAT: 0931-T13058-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T13058-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2407433-00-3

Target

Apoptosis, DYRK, CDK

Related Pathways

Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Apoptosis

Purity

0.992

Bioactivity

T025 is a pan CLK inhibitor with Kds of 4.8, 0.096, 6.5, 0.61, and 0.074 nM for CLK1-4, respectively. T025 displays anti-proliferative activities with IC50s of 30-300 nM in hematological and solid cancer cell lines. T025 can be used in studies about MYC-driven diseases.

Smiles

CNc1nc(NCc2ncccn2)c2c(c[nH]c2n1)-c1ccc2ncccc2c1

Molecular Formula

C21H18N8

Molecular Weight

382.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine

CAS Number	2407433-00-3
PubChem CID	133082038
IUPAC Name	2-N-methyl-4-N-(pyrimidin-2-ylmethyl)-5-quinolin-6-yl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Molecular Formula	C21H18N8
Molecular Weight	382.4
XLogP	3
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	29
Formal Charge	0
Complexity	527

SMILES

CNC1=NC2=C(C(=CN2)C3=CC4=C(C=C3)N=CC=C4)C(=N1)NCC5=NC=CC=N5

InChI

InChI=1S/C21H18N8/c1-22-21-28-19-18(20(29-21)27-12-17-24-8-3-9-25-17)15(11-26-19)13-5-6-16-14(10-13)4-2-7-23-16/h2-11H,12H2,1H3,(H3,22,26,27,28,29)

InChIKey

PMWVYONICYRLNY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2407433-00-3

CID: 133082038

Formula: C21H18N8

MW: 382.4

Interactive 3D Structure

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Computed Properties

Property	Value
Molecular Weight	382.4
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	382.16544261
Monoisotopic Mass	382.16544261
Topological Polar Surface Area	104 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	527
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
MBS5753993	T025

T025

Chemical Information

Alternative Products

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