T025

CAT: 0804-HY-112296-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-112296-02Size:10 mM - 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM) . T025 has an anti-tumor efficiency, mainly for MYC-driven disease research[1].

CAS Number

2407433-00-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; CDK; DYRK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/T025.html

Purity

99.64

Solubility

DMSO : 8.25 mg/mL (ultrasonic)

Smiles

CNC1=NC(NCC2=NC=CC=N2)=C(C(C3=CC=C(N=CC=C4)C4=C3)=CN5)C5=N1

Molecular Formula

C21H18N8

Molecular Weight

382.42

Precautions

H302, H315, H319

References & Citations

[1]Iwai K, et al. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability. EMBO Mol Med. 2018 Jun;10 (6) :e8289.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CLK; DYRK1; DYRK2

Chemical Information

N2-methyl-N4-(pyrimidin-2-ylmethyl)-5-(quinolin-6-yl)-7H-pyrrolo(2,3-d)pyrimidine-2,4-diamine

CAS Number	2407433-00-3
PubChem CID	133082038
IUPAC Name	2-N-methyl-4-N-(pyrimidin-2-ylmethyl)-5-quinolin-6-yl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
Molecular Formula	C21H18N8
Molecular Weight	382.4
XLogP	3
Topological Polar Surface Area	104
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Heavy Atom Count	29
Formal Charge	0
Complexity	527

SMILES

CNC1=NC2=C(C(=CN2)C3=CC4=C(C=C3)N=CC=C4)C(=N1)NCC5=NC=CC=N5

InChI

InChI=1S/C21H18N8/c1-22-21-28-19-18(20(29-21)27-12-17-24-8-3-9-25-17)15(11-26-19)13-5-6-16-14(10-13)4-2-7-23-16/h2-11H,12H2,1H3,(H3,22,26,27,28,29)

InChIKey

PMWVYONICYRLNY-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2407433-00-3

CID: 133082038

Formula: C21H18N8

MW: 382.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	382.4
XLogP3	3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	5
Exact Mass	382.16544261
Monoisotopic Mass	382.16544261
Topological Polar Surface Area	104 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	527
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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