MYCMI-6

• Product Name Alternative:

  NSC354961

• UNSPSC Description:

  MYCMI-6 (NSC354961) is a potent and selective endogenous MYC:MAX protein interactions inhibitor. MYCMI-6 blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with a Kd of 1.6?μM. MYCMI-6 inhibits tumor cell growth in a MYC-dependent manner (IC50apoptosis[1].

• Target Antigen:

  Apoptosis; c-Myc

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mycmi-6.html

• Purity:

  98.14

• Solubility:

  DMSO : 2.4 mg/mL (ultrasonic)

• Smiles:

  NC1=NC(N)=CC=C1/N=N/C2=CC3=NC4=CC=C(OCC)C=C4C(N)=C3C=C2

• Molecular Weight:

  373.41

• References & Citations:

  [1]Castell A, et al. A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation. Sci Rep. 2018 Jul 3;8(1):10064.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  681282-09-7