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0990CL

CAT: 0013-GTR19204144-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19204144-04Size:10 mg
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Description
0990CL is a specific inhibitor of heterotrimeric Gαi subunits, binding to GDP-bound Gα to disrupt α2AR-mediated cAMP signaling. In cellular models, it partially restores cAMP at low doses, while higher concentrations (e.g., 10μM) can impact cell viability. This tool compound is valuable for in vitro studies investigating GPCR and cAMP pathways in signal transduction research.
CAS Number
511514-03-7
Product Name Alternative
Heterotrimeric G-protein complex, Gαi subunit, cAMP, 0990CL
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.86% (May vary between batches)
Solubility
DMSO:45 mg/mL (131.03 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.82 mM)
Smiles
N (C=1N=C (C2=C (N1) C=CC=C2) C3=CC=CC=C3) C=4NC (C) (C) C=C (C) N4
Molecular Formula
C21H21N5
Molecular Weight
343.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
CAS Number511514-03-7
PubChem CID950615
IUPAC Name4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
Molecular FormulaC21H21N5
Molecular Weight343.4
XLogP3.7
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity561
SMILES
CC1=CC(N=C(N1)NC2=NC3=CC=CC=C3C(=N2)C4=CC=CC=C4)(C)C
InChI
InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)
InChIKey
DXICUHJLOMNKOU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
CAS: 511514-03-7
CID: 950615
Formula: C21H21N5
MW: 343.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.4
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass343.17969569
Monoisotopic Mass343.17969569
Topological Polar Surface Area62.2 Ų
Heavy Atom Count26
Formal Charge0
Complexity561
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
LVA51403-010990CL

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