0990CL

CAT: 0931-T13983-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T13983-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

511514-03-7

Target

CAMP, Others, Adrenergic Receptor

Related Pathways

Neuroscience, GPCR/G Protein, Others

Purity

0.9912

Bioactivity

0990CL is an effective heterotrimer Gαi subunit specific inhibitor, which can interact with purified Go± in GDP-bound state, and can block α2AR mediated cAMP regulation. In the cell model, low concentration of 0990CL could partially restore cAMP level, and high concentration of 0990CL (10μM) began to have negative effects on cell viability.

Smiles

N(C=1N=C(C2=C(N1)C=CC=C2)C3=CC=CC=C3)C=4NC(C)(C)C=C(C)N4

Molecular Formula

C21H21N5

Molecular Weight

343.42

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine

CAS Number	511514-03-7
PubChem CID	950615
IUPAC Name	4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine
Molecular Formula	C21H21N5
Molecular Weight	343.4
XLogP	3.7
Topological Polar Surface Area	62.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	26
Formal Charge	0
Complexity	561

SMILES

CC1=CC(N=C(N1)NC2=NC3=CC=CC=C3C(=N2)C4=CC=CC=C4)(C)C

InChI

InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)

InChIKey

DXICUHJLOMNKOU-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 511514-03-7

CID: 950615

Formula: C21H21N5

MW: 343.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	343.4
XLogP3	3.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	343.17969569
Monoisotopic Mass	343.17969569
Topological Polar Surface Area	62.2 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	561
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
LVA51403-01	0990CL

0990CL

Chemical Information

Alternative Products

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