C5aR1 antagonist 1
CAT:
804-HY-163378
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

C5aR1 antagonist 1
- CAS Number: 2365325-67-1
- UNSPSC Description: C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases[1].
- Target Antigen: Complement System
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/c5ar1-antagonist-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3
- Molecular Weight: 497.53
- References & Citations: [1]Hubler, F., D. Renneberg, et al. "Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity." Journal of Medicinal Chemistry. 2024 March 04.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported