C5aR1 antagonist 1

• UNSPSC Description:

  C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases[1].

• Target Antigen:

  Complement System

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/c5ar1-antagonist-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3

• Molecular Weight:

  497.53

• References & Citations:

  [1]Hubler, F., D. Renneberg, et al. "Discovery and Characterization of a New Class of C5aR1 Antagonists Showing In Vivo Activity." Journal of Medicinal Chemistry. 2024 March 04.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2365325-67-1