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Tyrphostin A25

CAT: 0013-GTR19201668-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201668-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrphostin A25 (Tyrphostin AG 82) is a specific EGFR tyrosine kinase inhibitor and GPR35 agonist, with an IC50 of 0.94 μM and an EC50 of 5.3 μM for GPR35. It is used in research on EGFR-driven cancers and GPR35 signaling, employing in vitro assays and in vivo models for therapeutic investigation.
CAS Number
118409-58-8
Product Name Alternative
AG 82, AG82, AG-82, GPR35, EGFR, RG 50875, RG50875, RG-50875, Tyrphostin AG 82, Tyrphostin A25
Field of Research
Cardiovascular Research, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Purity
98.76% (May vary between batches)
Smiles
C (=C (C#N) C#N) C1=CC (O) =C (O) C (O) =C1
Molecular Formula
C10H6N2O3
Molecular Weight
202.17
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tyrphostin 25

2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile is a benzenetriol.

CAS Number118409-58-8
PubChem CID2061
IUPAC Name2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile
Molecular FormulaC10H6N2O3
Molecular Weight202.17
XLogP0.9
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity329
SMILES
C1=C(C=C(C(=C1O)O)O)C=C(C#N)C#N
InChI
InChI=1S/C10H6N2O3/c11-4-7(5-12)1-6-2-8(13)10(15)9(14)3-6/h1-3,13-15H
InChIKey
YZOFLYUAQDJWKV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin 25
CAS: 118409-58-8
CID: 2061
Formula: C10H6N2O3
MW: 202.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight202.17
XLogP30.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass202.03784206
Monoisotopic Mass202.03784206
Topological Polar Surface Area108 Ų
Heavy Atom Count15
Formal Charge0
Complexity329
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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