BI-4924

• Description:

  BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].

• UNSPSC:

  12352005

• Target:

  Phosphoglycerate Dehydrogenase (PHGDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/bi-4924.html

• Purity:

  99.55

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (O) CS (=O) (C1=CC=C ([C@H] (NC (C (N2C) =CC3=C2C=C (C) C (Cl) =C3Cl) =O) CO) C=C1) =O

• Molecular Formula:

  C21H20Cl2N2O6S

• Molecular Weight:

  499.36

• References & Citations:

  [1]Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2244452-09-1