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Tyrphostin A46

CAT: 0013-GTR19200479-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19200479-01Size:25 mg
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Description
Tyrphostin A46 is a selective inhibitor of the epidermal growth factor receptor (EGFR) . It is widely used in biochemical research to study EGFR-mediated signaling pathways in both cellular and animal models of proliferation and oncology.
CAS Number
118409-59-9
Field of Research
Protein Biochemistry
Smiles
C (=C (C (N) =O) C#N) C1=CC (O) =C (O) C=C1
Molecular Formula
C10H8N2O3
Molecular Weight
204.18
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tyrphostin A46

Tyrphostin A46 is a protein tyrosine kinase inhibitor that selectively inhibits EGFR kinase, involved in signaling pathways. (NCI)

CAS Number118409-59-9
PubChem CID5328768
IUPAC Name(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Molecular FormulaC10H8N2O3
Molecular Weight204.18
XLogP0.4
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count15
Formal Charge0
Complexity329
SMILES
C1=CC(=C(C=C1/C=C(\C#N)/C(=O)N)O)O
InChI
InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
InChIKey
USOXQZNJFMKTKJ-XVNBXDOJSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin A46
CAS: 118409-59-9
CID: 5328768
Formula: C10H8N2O3
MW: 204.18
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight204.18
XLogP30.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass204.05349212
Monoisotopic Mass204.05349212
Topological Polar Surface Area107 Ų
Heavy Atom Count15
Formal Charge0
Complexity329
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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