GS 283

CAT: 0013-GTR19198335-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19198335-01Size:25 mg

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Description

GS 283 is a calcium channel antagonist that also exhibits weak antagonistic activity at histamine and muscarinic receptors, as demonstrated in rodent tracheal smooth muscle preparations. This pharmacological profile makes it a useful research tool for studying airway physiology, bronchoconstriction mechanisms, and calcium signaling in both in vitro and ex vivo experimental models.

CAS Number

149440-36-8

Field of Research

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Smiles

C (C=1C=2C (=CC (O) =C (O) C2) CCN1) C3=CC=C (OC) C=C3

Molecular Formula

C17H17NO3

Molecular Weight

283.32

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

GS 283

cpd has a Ca(2+) antagonistic action & a weak histamine & muscarinic receptor blocking activity in rat & guinea pig tracheal smooth muscle; its mode of action is inhibition of calcium influx from plasma membrane & also release from sarcoplasmic reticulum

CAS Number	149440-36-8
PubChem CID	136170969
IUPAC Name	1-[(4-methoxyphenyl)methyl]-3,4-dihydroisoquinoline-6,7-diol
Molecular Formula	C17H17NO3
Molecular Weight	283.32
XLogP	2.5
Topological Polar Surface Area	62.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	21
Formal Charge	0
Complexity	376

SMILES

COC1=CC=C(C=C1)CC2=NCCC3=CC(=C(C=C32)O)O

InChI

InChI=1S/C17H17NO3/c1-21-13-4-2-11(3-5-13)8-15-14-10-17(20)16(19)9-12(14)6-7-18-15/h2-5,9-10,19-20H,6-8H2,1H3

InChIKey

KEZZGJVNRZSQGG-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 149440-36-8

CID: 136170969

Formula: C17H17NO3

MW: 283.32

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	283.32
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Exact Mass	283.12084340
Monoisotopic Mass	283.12084340
Topological Polar Surface Area	62.1 Å²
Heavy Atom Count	21
Formal Charge	0
Complexity	376
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19194319	ICR 283
GTR19217396-01	BGB-283
GTR19203632-01	LLY-283
GTR19276174-01	CRBN ligand-283
GTR19263361-01	Antibacterial agent 283
GTR19199423	SDZ 283-910
GTR19154766-01	GS-143
GTR19237823-01	GS-7682
GTR19222018-01	GS-443902
GTR19194422	GS-7339

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GS 283

Chemical Information

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