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LLY-283

CAT: 0013-GTR19203632-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203632-01Size:10 mg
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Description
LLY-283 is a potent, selective, and orally bioavailable inhibitor of the PRMT5:MEP50 complex, demonstrating high affinity with a Kd of 6 nM. It exhibits robust antitumor activity and is a valuable chemical probe for investigating PRMT5 biology in cancer research, both in cellular and animal models.
CAS Number
2040291-27-6
Product Name Alternative
Histone Methyltransferase, HistoneMethyltransferase, MEP50, LLY283, LLY-283, LLY 283, PRMT5
Field of Research
Epigenetics & Chromatin
Purity
98.79% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (11.68 mM) ; H2O:3.57 mg/mL (10.43 mM) ; DMSO:112.5 mg/mL (328.61 mM)
Smiles
[H][C@@]1 (O[C@H] ([C@H] (O) [C@@H]1O) n1ccc2c (N) ncnc12) [C@H] (O) c1ccccc1
Molecular Formula
C17H18N4O4
Molecular Weight
342.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lly-283

LLY283 is lLY-283 is a novel and selective inhibitor of protein arginine methyltransferase 5 (PRMT5). LLY-283 inhibits PRMT5 enzymatic activity in vitro and in cells with IC50 of 22 nM and 25 nM, respectively. LLY-283 shows antitumor activity.

CAS Number2040291-27-6
PubChem CID122669401
IUPAC Name(2R,3R,4S,5R)-2-(4-aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[(R)-hydroxy(phenyl)methyl]oxolane-3,4-diol
Molecular FormulaC17H18N4O4
Molecular Weight342.35
XLogP0.2
Topological Polar Surface Area127
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity464
SMILES
C1=CC=C(C=C1)[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O
InChI
InChI=1S/C17H18N4O4/c18-15-10-6-7-21(16(10)20-8-19-15)17-13(24)12(23)14(25-17)11(22)9-4-2-1-3-5-9/h1-8,11-14,17,22-24H,(H2,18,19,20)/t11-,12+,13-,14-,17-/m1/s1
InChIKey
WWOOWAHTEXIWBO-QFRSUPTLSA-N
Chemical Structure
2D Structure
2D structure of Lly-283
CAS: 2040291-27-6
CID: 122669401
Formula: C17H18N4O4
MW: 342.35
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight342.35
XLogP30.2
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass342.13280507
Monoisotopic Mass342.13280507
Topological Polar Surface Area127 Ų
Heavy Atom Count25
Formal Charge0
Complexity464
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
HY-107777-01LLY-283
BL166665LLY 283
A19754-50LLY-283 50mg
A19754-5LLY-283 5mg
A19754-100LLY-283 100mg
A19754-10LLY-283 10mg

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