Products for Research Use Only
RegisterLogin

PG-116800

CAT: 0013-GTR19196736-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19196736-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PG-116800 (also known as PG-530742) is a synthetic matrix metalloproteinase (MMP) inhibitor investigated for its potential in osteoarthritis treatment. Research, including in vitro enzymatic assays and in vivo animal models of joint disease, has explored its role in modulating cartilage degradation.
CAS Number
291533-11-4
Product Name Alternative
PG 530742, PG 116800, PG116800, PG-116800, PG-530742, PG530742, PGE7113313, PGE-7113313, PGE 7113313, MMP
Field of Research
Protein Biochemistry
Purity
98.02% (May vary between batches)
Solubility
DMSO:50 mg/mL (99.69 mM)
Smiles
S (NC (CC#CCN1CCOCC1) C (O) =O) (=O) (=O) C2=CC=C (NC (=O) C3=CC=C (OC) C=C3) C=C2
Molecular Formula
C24H27N3O7S
Molecular Weight
501.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PG-116800

PG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis. By inhibiting these MMPs, it potentially limits cartilage degradation and disease progression. Studies are currently assessing the efficacy and safety of PG-530742 in the treatment of mild to moderate knee osteoarthritis.

CAS Number291533-11-4
PubChem CID9848869
IUPAC Name2-[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonylamino]-6-morpholin-4-ylhex-4-ynoic acid
Molecular FormulaC24H27N3O7S
Molecular Weight501.6
XLogP-0.8
Topological Polar Surface Area143
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity870
SMILES
COC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)S(=O)(=O)NC(CC#CCN3CCOCC3)C(=O)O
InChI
InChI=1S/C24H27N3O7S/c1-33-20-9-5-18(6-10-20)23(28)25-19-7-11-21(12-8-19)35(31,32)26-22(24(29)30)4-2-3-13-27-14-16-34-17-15-27/h5-12,22,26H,4,13-17H2,1H3,(H,25,28)(H,29,30)
InChIKey
JAYVKNDQKXUNOJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PG-116800
CAS: 291533-11-4
CID: 9848869
Formula: C24H27N3O7S
MW: 501.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.6
XLogP3-0.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count9
Exact Mass501.15697138
Monoisotopic Mass501.15697138
Topological Polar Surface Area143 Ų
Heavy Atom Count35
Formal Charge0
Complexity870
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19212143-01PG-11047
GTR19184740PG 34
GTR19239040-01PG-PS
GTR19262931-01LPS-PG
GTR19213749-01Egg PG
GTR19150494-01PG-901
GTR19150517-01PG-911
GTR19029282PG-931
GTR18919013-01PG 931 acetate
GTR19248608-0118:2 PG

Alternative Products

CatalogName
BUP03218-01PG-116800
HY-14240-01PG 116800
P1276PG-Host9
HY-16395-01PG-11047
T210365-01LPS-PG
TP1953PG-931
HY-159614PG-PS
CCP3064-01PG 931
sc-358839APG 01
M37852-01Egg PG

Popular Products