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SI-2

CAT: 0013-GTR19196500-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19196500-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SI-2 is a potent and selective small molecule inhibitor of the steroid receptor coactivator-3 (SRC-3/AIB1) . It effectively degrades SRC-3 protein and suppresses its transcriptional activity, inducing selective apoptosis in breast cancer cells at low nanomolar concentrations while sparing normal cells. This compound is a valuable chemical probe for studying SRC-3 biology in cancer research, supporting both in vitro and in vivo experimental applications.
CAS Number
223788-33-8
Product Name Alternative
EPH116, EPH-116, EPH 116, steroid receptor coactivator-3, SI 2, SI-2, SI2
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
97.85% (May vary between batches)
Solubility
DMSO:55 mg/mL (207.3 mM)
Smiles
CN1C=2C (N=C1NN=C (C) C3=CC=CC=N3) =CC=CC2
Molecular Formula
C15H15N5
Molecular Weight
265.31
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine
CAS Number223788-33-8
PubChem CID10220948
IUPAC Name1-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine
Molecular FormulaC15H15N5
Molecular Weight265.31
XLogP2.9
Topological Polar Surface Area55.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity356
SMILES
C/C(=N\NC1=NC2=CC=CC=C2N1C)/C3=CC=CC=N3
InChI
InChI=1S/C15H15N5/c1-11(12-7-5-6-10-16-12)18-19-15-17-13-8-3-4-9-14(13)20(15)2/h3-10H,1-2H3,(H,17,19)/b18-11+
InChIKey
JNNXERNBPXXNLK-WOJGMQOQSA-N
Chemical Structure
2D Structure
2D structure of 1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazol-2-amine
CAS: 223788-33-8
CID: 10220948
Formula: C15H15N5
MW: 265.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight265.31
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass265.13274550
Monoisotopic Mass265.13274550
Topological Polar Surface Area55.1 Ų
Heavy Atom Count20
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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