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PJ34 (hydrochloride)

CAT: 0804-HY-13688-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13688-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PJ34 hydrochloride is an inhibitor of PARP1/2 with IC50 of 110 nM and 86 nM, respectively.
CAS Number
344458-15-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PJ34-hydrochloride.html
Purity
99.91
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)
Smiles
O=C(NC(C=C1C2=C3C=CC=C2)=CC=C1NC3=O)CN(C)C.Cl
Molecular Formula
C17H18ClN3O2
Molecular Weight
331.80
Precautions
H302, H315, H319, H335
References & Citations
[1]Iwashita A, et al. A novel and potent poly (ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3- (4-phenyl-3,6-dihydro-1 (2H) -pyridinyl) propyl]-4 (3H) -quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph|[2]Haddad M, et al. Anti-inflammatory effects of PJ34, a poly (ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149 (1) :23-30.|[3]Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7 (1) :2268.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP; PARP1; PARP2
Citation 01
Acta Biomater. 2022 Jul 15:147:327-341.|Anim Cells Syst. 2022 Aug 3;26 (4) :192-202.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Sci Rep. 2017 May 23;7 (1) :2268.|Antioxidants (Basel) . 2024 Apr 26, 13 (5), 525.|Antioxidants (Basel) . 2024 Apr 26;13 (5) :525.|Apoptosis. 2021 Dec;26 (11-12) :600-611.|Autophagy. 2025 May 8:1-24.|Biochim Biophys Acta Mol Basis Dis. 2024 Apr 22;1870 (5) :167190.|Bioorg Chem. 2024 Jun:147:107412.|bioRxiv. 2023 Oct 4.|bioRxiv. 2024 Sep 19:2024.09.19.613696.|bioRxiv. 2025 March 26.|Cancer Lett. 2021 Nov 1:520:26-37.|Cell Mol Life Sci. 2025 Oct 25;82 (1) :363.|Free Radic Biol Med. 2022 Feb 1:179:1-10.|J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2501743.|J Invest Dermatol. 2024 May 30:S0022-202X (24) 00384-1.|J Transl Med. 2024 Dec 27;22 (1) :1153.|J Virol. 2021 Jul 26;95 (16) :e0076021.|Mol Med Rep. 2024 Jun;29 (6) :102.|Nat Aging. 2024 May 9.|Norges teknisk-naturvitenskapelige universitet. 2024.|Norges teknisk-naturvitenskapelige universitet. 2025.|Nottingham Trent University. 2023 Sep 12.|Part Fibre Toxicol. 2020 Jun 8;17 (1) :23. |Patent. US20180263995A1.|Proc Natl Acad Sci U S A. 2023 Mar 28;120 (13) :e2213857120.|Regen Ther. 2023 Nov 10:24:592-601.|Research Square Print. 2022.|Sci Signal. 2023 Jan 17;16 (768) :eabh1083.

Chemical Information

PJ-34 hydrochloride

PJ34 hydrochloride is a hydrochloride salt prepared from equimolar amounts of PJ34 and hydrochloric acid. It has a role as an antiatherosclerotic agent, an antineoplastic agent, an angiogenesis inhibitor, an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, a neuroprotective agent, an anti-inflammatory agent, an apoptosis inducer and a cardioprotective agent. It contains a PJ34(1+).

CAS Number344458-15-7
PubChem CID16760621
IUPAC Name2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide;hydrochloride
Molecular FormulaC17H18ClN3O2
Molecular Weight331.8
Topological Polar Surface Area61.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity438
SMILES
CN(C)CC(=O)NC1=CC2=C(C=C1)NC(=O)C3=CC=CC=C32.Cl
InChI
InChI=1S/C17H17N3O2.ClH/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H
InChIKey
RURAZZMDMNRXMI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PJ-34 hydrochloride
CAS: 344458-15-7
CID: 16760621
Formula: C17H18ClN3O2
MW: 331.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight331.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass331.1087545
Monoisotopic Mass331.1087545
Topological Polar Surface Area61.4 Ų
Heavy Atom Count23
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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