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Dmt-2'fluoro-da (bz) amidite

CAT: 0013-GTR19191171Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191171Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This product is Dmt-2'fluoro-da (bz) amidite, a 2'-fluoro-modified phosphoramidite building block used to synthesize antisense oligonucleotides with high RNA affinity and nuclease resistance. It is a key intermediate for creating research compounds applied in both in vitro and in vivo studies targeting specific RNA sequences.
CAS Number
136834-22-5
Product Name Alternative
Dmt-2'fluoro-da (bz) amidite, Dmt2'fluoroda (bz) amidite, Dmt 2'fluoro da (bz) amidite, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology, Musculoskeletal & Connective Tissue Research
Purity
98.15% (May vary between batches)
Solubility
DMSO:50 mg/mL (57.08 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (2.85 mM)
Smiles
COc1ccc (cc1) C (OC[C@H]1O[C@H] ([C@H] (F) [C@@H]1OP (OCCC#N) N (C (C) C) C (C) C) n1cnc2c (NC (=O) c3ccccc3) ncnc12) (c1ccccc1) c1ccc (OC) cc1
Molecular Formula
C47H51FN7O7P
Molecular Weight
875.92
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)-phenylmethoxy)methyl)-4-(2-cyanoethoxy-(di(propan-2-yl)amino)phosphanyl)oxy-3-fluorooxolan-2-yl)purin-6-yl)benzamide
CAS Number136834-22-5
PubChem CID12042896
IUPAC NameN-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-fluorooxolan-2-yl]purin-6-yl]benzamide
Molecular FormulaC47H51FN7O7P
Molecular Weight875.9
XLogP7.5
Topological Polar Surface Area155
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count19
Heavy Atom Count63
Formal Charge0
Complexity1420
SMILES
CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
InChI
InChI=1S/C47H51FN7O7P/c1-31(2)55(32(3)4)63(60-27-13-26-49)62-42-39(61-46(40(42)48)54-30-52-41-43(50-29-51-44(41)54)53-45(56)33-14-9-7-10-15-33)28-59-47(34-16-11-8-12-17-34,35-18-22-37(57-5)23-19-35)36-20-24-38(58-6)25-21-36/h7-12,14-25,29-32,39-40,42,46H,13,27-28H2,1-6H3,(H,50,51,53,56)/t39-,40-,42-,46-,63?/m1/s1
InChIKey
VCCMVPDSLHFCBB-MSIRFHFKSA-N
Chemical Structure
2D Structure
2D structure of N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)-phenylmethoxy)methyl)-4-(2-cyanoethoxy-(di(propan-2-yl)amino)phosphanyl)oxy-3-fluorooxolan-2-yl)purin-6-yl)benzamide
CAS: 136834-22-5
CID: 12042896
Formula: C47H51FN7O7P
MW: 875.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight875.9
XLogP37.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count13
Rotatable Bond Count19
Exact Mass875.35716215
Monoisotopic Mass875.35716215
Topological Polar Surface Area155 Ų
Heavy Atom Count63
Formal Charge0
Complexity1420
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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MBS5797820Dmt-2'fluoro-da(bz) amidite
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HY-154261Rev 2’-O-MOE-A (Bz) -5’-amidite
T75210-01Rev 2'-O-MOE-A (Bz) -5'-amidite
MBS5827122Rev 2'-O-MOE-A(Bz)-5'-amidite
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