MC-DM1

CAT: 0013-GTR19189703-02Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19189703-02Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MC-DM1 is a drug-linker conjugate designed for constructing antibody-drug conjugates (ADCs) . It incorporates the cytotoxic maytansinoid DM1, a microtubule-disrupting agent, linked via the MC moiety. This reagent is widely used in cancer research for developing and evaluating targeted therapies in both in vitro and in vivo experimental models.

CAS Number

1375089-56-7

Smiles

[H][C@@]12O[C@@]1 (C) [C@H] (CC (=O) N (C) c1cc (C\C (C) =C/C=C/[C@@H] (OC) [C@@]3 (O) C[C@] ([H]) (OC (=O) N3) [C@H]2C) cc (OC) c1Cl) OC (=O) [C@H] (C) N (C) C (=O) CCCCCN1C (=O) C=CC1=O |c:17,61, t:19|

Molecular Formula

C42H55ClN4O12

Molecular Weight

843.37

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

CID 76072941

CAS Number	1375089-56-7
PubChem CID	76072941
IUPAC Name	[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03,5]hexacosa-10,12,14(26),16,18-pentaen-6-yl] (2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoyl-methylamino]propanoate
Molecular Formula	C42H55ClN4O12
Molecular Weight	843.4
XLogP	2.3
Topological Polar Surface Area	194
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	12
Heavy Atom Count	59
Formal Charge	0
Complexity	1690

SMILES

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)[C@H](C)N(C)C(=O)CCCCCN5C(=O)C=CC5=O)C)\C)OC)(NC(=O)O2)O

InChI

InChI=1S/C42H55ClN4O12/c1-24-13-12-14-31(56-8)42(54)23-30(57-40(53)44-42)25(2)38-41(4,59-38)32(22-36(51)46(6)28-20-27(19-24)21-29(55-7)37(28)43)58-39(52)26(3)45(5)33(48)15-10-9-11-18-47-34(49)16-17-35(47)50/h12-14,16-17,20-21,25-26,30-32,38,54H,9-11,15,18-19,22-23H2,1-8H3,(H,44,53)/b14-12+,24-13+/t25-,26+,30+,31-,32+,38+,41+,42+/m1/s1

InChIKey

UGBPANNIQRLRII-RJPAQOSPSA-N

Chemical Structure

2D Structure

CAS: 1375089-56-7

CID: 76072941

Formula: C42H55ClN4O12

MW: 843.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	843.4
XLogP3	2.3
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	12
Exact Mass	842.3505009
Monoisotopic Mass	842.3505009
Topological Polar Surface Area	194 Å²
Heavy Atom Count	59
Formal Charge	0
Complexity	1690
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR18577580-01	DM1 Antibody
GTR19174160-01	SMCC-DM1
GTR19224945-01	SPP-DM1
GTR18406314-01	DM1 Antibody
GTR18777881-01	DM1 Antibody
GTR19156342-01	DM1-MCC

Alternative Products

Catalog	Name
MBS5785442	MC-DM1
T205792-01	MC-ADAA-S-NCA-DM1
ADC-P-033	DM1
HY-132250-01	MCC-DM1
DZB10551-01	SMCC-DM1
T208206-01	Ahx-DM1
MBS3615996-01	DM1-SMe
MBS384636-01	DM1-SMCC
MBS3613084-01	DM1-MCC
C12196-01	DM1 (Mertansine)

MC-DM1

Chemical Information

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