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Itacnosertib

CAT: 0013-GTR19189550-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19189550-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Itacnosertib (TP-0184) is an orally bioavailable small molecule inhibitor targeting ACRV1 (ALK-2), FLT3, and JAK2. It demonstrates antitumor activity by overcoming FLT3 inhibitor resistance and synergizing with venetoclax in AML models, as shown in preclinical in vitro and in vivo studies.
CAS Number
1628870-27-8
Product Name Alternative
Itacnosertib, TP 0184, TP0184, TP-0184
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.38% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.13 mM) ; DMSO:10 mg/mL (21.34 mM)
Smiles
N=1C=CC (=NC1NC2=CC=C (C (OC) =C2) N3CCN (C) CC3) NC=4C=CC=NC4C5=NC=CC=C5
Molecular Formula
C26H28N8O
Molecular Weight
468.55
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

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BA4911-1Itacnosertib
E1732-25mgItacnosertib (TP-0184)
T84696-01Itacnosertib (hydrocholide)
HY-109179A-01Itacnosertib (hydrochloride)

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