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Itacnosertib

CAT: 0931-T39104-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T39104-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1628870-27-8
Target
FLT, Akt, mTOR, JAK, STAT, PI3K, ALK, TGF-beta/Smad
Related Pathways
JAK/STAT signaling, Stem Cells, PI3K/Akt/mTOR signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic, Cytoskeletal Signaling
Purity
0.9938
Bioactivity
Itacnosertib (TP-0184) is an orally available ACRV1 (ALK-2), FLT3 and JAK2 inhibitor that inhibits the growth of tumor cells overexpressing ALK-2, overcomes FLT3 inhibitor resistance and synergistically inhibits AML growth with venetoclax, and possesses potential antitumor and antileukemic activity.
Smiles
N=1C=CC(=NC1NC2=CC=C(C(OC)=C2)N3CCN(C)CC3)NC=4C=CC=NC4C5=NC=CC=C5
Molecular Formula
C26H28N8O
Molecular Weight
468.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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BA4911-1Itacnosertib
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HY-109179A-01Itacnosertib (hydrochloride)
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