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BIX 02565

CAT: 0013-GTR19188352-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188352-02Size:5 mg
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Description
BIX 02565 is a highly potent and selective small molecule inhibitor of ribosomal S6 kinase 2 (RSK2), exhibiting an IC50 of 1.1 nM. This compound is a valuable research tool for investigating RSK2 signaling in cellular models of cancer and neurological disorders, with utility demonstrated in both in vitro and in vivo experimental systems.
CAS Number
1311367-27-7
Product Name Alternative
RSK2, S6Kinase, S6K, S6 Kinase, Ribosomal S6 Kinase (RSK), BIX02565, BIX-02565, BIX 02565, inhibit, Inhibitor, LRRK2
Field of Research
Cell Biology, Signal Transduction
Purity
97.44% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.18 mM) ; DMSO:20 mg/mL (43.61 mM)
Smiles
C[C@@H]1CCNC (=O) c2cc3ccc (cc3n12) C (=O) Nc1nc2ccccc2n1CCCN (C) C
Molecular Formula
C26H30N6O2
Molecular Weight
458.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bix 02565
CAS Number1311367-27-7
PubChem CID53246941
IUPAC Name(5R)-N-[1-[3-(dimethylamino)propyl]benzimidazol-2-yl]-5-methyl-1-oxo-2,3,4,5-tetrahydro-[1,4]diazepino[1,2-a]indole-8-carboxamide
Molecular FormulaC26H30N6O2
Molecular Weight458.6
XLogP3.1
Topological Polar Surface Area84.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity747
SMILES
C[C@@H]1CCNC(=O)C2=CC3=C(N12)C=C(C=C3)C(=O)NC4=NC5=CC=CC=C5N4CCCN(C)C
InChI
InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1
InChIKey
ZHMXXVNQAFCXKK-QGZVFWFLSA-N
Chemical Structure
2D Structure
2D structure of Bix 02565
CAS: 1311367-27-7
CID: 53246941
Formula: C26H30N6O2
MW: 458.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.6
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass458.24302422
Monoisotopic Mass458.24302422
Topological Polar Surface Area84.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity747
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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