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BIX-01294

CAT: 0013-GTR19167473-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167473-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BIX-01294 is a cell-permeable, potent, and selective inhibitor of the histone methyltransferase G9a (IC50 = 1.9 μM) . It is widely used in epigenetic research to probe the role of histone H3 lysine 9 methylation in gene silencing, cellular differentiation, and has demonstrated utility in both in vitro and in vivo experimental models.
CAS Number
935693-62-2
Product Name Alternative
PRMT1, recurrent, p21, SUV39H1 (H320R), inhibit, Inhibitor, MLKL, p53, Histone Methyltransferase, HistoneMethyltransferase, Gadd45a, G9a, H3K9me2, H3K9me3, Cdkn1a, Autophagy, BIX 01294, BIX01294, BIX-01294
Field of Research
Epigenetics & Chromatin, Neuroscience, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
Histone methyl transferase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 50 mg/ml) .
Smiles
N (C=1C2=C (N=C (N1) N3CCN (C) CCC3) C=C (OC) C (OC) =C2) C4CCN (CC5=CC=CC=C5) CC4
Molecular Formula
C28H38N6O2 • 3HCl
Molecular Weight
600.0
Storage Conditions
RT
Notes
For research use only.
Other Product Names
2- (Hexahydro-4-methyl-1H-1,4-diazepin-1-yl) -6,7-dimethoxy-N-[1- (phenylmethyl) -4-piperidinyl]-4-quinazolinamine, trihydrochloride

Chemical Information

N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine is a member of piperidines.

CAS Number935693-62-2
PubChem CID25150857
IUPAC NameN-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Molecular FormulaC28H38N6O2
Molecular Weight490.6
XLogP4.5
Topological Polar Surface Area66
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity656
SMILES
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
InChI
InChI=1S/C28H38N6O2/c1-32-12-7-13-34(17-16-32)28-30-24-19-26(36-3)25(35-2)18-23(24)27(31-28)29-22-10-14-33(15-11-22)20-21-8-5-4-6-9-21/h4-6,8-9,18-19,22H,7,10-17,20H2,1-3H3,(H,29,30,31)
InChIKey
OSXFATOLZGZLSK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
CAS: 935693-62-2
CID: 25150857
Formula: C28H38N6O2
MW: 490.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight490.6
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass490.30562448
Monoisotopic Mass490.30562448
Topological Polar Surface Area66 Ų
Heavy Atom Count36
Formal Charge0
Complexity656
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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