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AV123

CAT: 0013-GTR19188162-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188162-01Size:25 mg
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Description
AV123 is a non-cytotoxic, small-molecule inhibitor of RIPK1 (IC50 = 12.12 μM) that selectively blocks TNF-α-induced necroptosis (EC50 = 1.7 μM) without affecting apoptosis. Its application in research extends to studying necroptosis-related pathologies, including ischemia-reperfusion injury, neurodegenerative diseases, and inflammatory conditions, in both cellular and animal models.
CAS Number
233605-81-7
Field of Research
Cell Biology, Signal Transduction
Smiles
N (=O) (=O) C=1C=C2C (N=C (NCCCC) N2) =CC1
Molecular Formula
C11H14N4O2
Molecular Weight
234.25
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 10823582
CAS Number233605-81-7
PubChem CID10823582
IUPAC NameN-butyl-6-nitro-1H-benzimidazol-2-amine
Molecular FormulaC11H14N4O2
Molecular Weight234.25
XLogP2.9
Topological Polar Surface Area86.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count17
Formal Charge0
Complexity269
SMILES
CCCCNC1=NC2=C(N1)C=C(C=C2)[N+](=O)[O-]
InChI
InChI=1S/C11H14N4O2/c1-2-3-6-12-11-13-9-5-4-8(15(16)17)7-10(9)14-11/h4-5,7H,2-3,6H2,1H3,(H2,12,13,14)
InChIKey
KCMYEMHXIIFYLP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 10823582
CAS: 233605-81-7
CID: 10823582
Formula: C11H14N4O2
MW: 234.25
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight234.25
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass234.11167570
Monoisotopic Mass234.11167570
Topological Polar Surface Area86.5 Ų
Heavy Atom Count17
Formal Charge0
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-151369-01AV123

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