AV123

CAT: 0931-MF-0052519-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0052519-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
233605-81-7
Target
Others|||RIP kinase
Related Pathways
Others|||NF-?B|||Apoptosis
Bioactivity
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with an IC50 of 12.12 ?M. It blocks TNF-?-induced necroptosis with an EC50 of 1.7 ?M, but not apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart, and kidney, inflammatory diseases, neurodegenerative diseases, and infectious diseases [1].
Smiles
N(=O)(=O)C=1C=C2C(N=C(NCCCC)N2)=CC1
Molecular Formula
C11H14N4O2
Molecular Weight
234.25
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

CatalogName
MBS5803046AV123

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