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AV123

CAT: 0804-HY-151369-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-151369-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 μM) . AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases[1].
CAS Number
233605-81-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/av123.html
Purity
99.60
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-]
Molecular Formula
C11H14N4O2
Molecular Weight
234.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Benchekroun M, et al. Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem. 2020 Sep 1;201:112337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T60316-01AV123

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