D-threo-PDMP (hydrochloride)
CAT:
804-HY-116392F-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
D-threo-PDMP (hydrochloride)
- CAS Number: 139889-62-6
- UNSPSC Description: D-threo-PDMP hydrochloride is a glucosylceramide (GlcCer) synthase inhibitor that inhibits glucosylceramide (GlcCer) and lactosylceramide (LacCer) levels in B16 melanoma cells. D-threo-PDMP hydrochloride lacks reactivity to the other two surface antigens anti-melanoma monoclonal antibodies M562 and M622 and the major histocompatibility antigen anti-H-2KbDb monoclonal antibody, so it is specific for B16 melanoma sex[1].
- Target Antigen: Others
- Type: Reference compound
- Related Pathways: Others
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/d-threo-pdmp-hydrochloride.html
- Purity: 98.0
- Solubility: Ethanol : 50 mg/mL (ultrasonic)
- Smiles: CCCCCCCCCC(N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2)=O.Cl[H]
- Molecular Weight: 427.02
- References & Citations: [1]Inokuchi J, et al. Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells. J Cell Physiol. 1989 Dec;141(3):573-83.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
- Clinical Information: No Development Reported