DL-threo-PPMP (hydrochloride)

DL-threo-PPMP (hydrochloride)

• CAS Number: 139974-41-7
• UNSPSC Description: DL-threo-PPMP hydrochloride is an inhibitor of sphingosine synthetase in Plasmodium falciparum. DL-threo-PPMP hydrochloride inhibits the activity of sphingosine synthetase (sphingosine synthetase) by binding to a substrate that mimics sphingosine. This inhibition leads to a rapid decline in sensitive sphingomyelin synthase (SSS) activity, selectively disrupting the interconnected tubular network of TVM in the cytoplasm of the host cell, and this inhibition also blocks the proliferation of the parasite. DL-threo-PPMP hydrochloride can be used in the study of malaria parasite biology and the search for new antimalarial strategies[1].
• Target Antigen: Parasite
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/dl-threo-ppmp-hydrochloride.html
• Smiles: O=C(N[C@@H]([C@@H](C1=CC=CC=C1)O)CN2CCOCC2)CCCCCCCCCCCCCCC.Cl
• Molecular Weight: 511.18
• References & Citations: [1]Lauer S A, et al. Sphingolipid synthesis as a target for chemotherapy against malaria parasites[J]. Proceedings of the National Academy of Sciences, 1995, 92(20): 9181-9185.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported