4-Hydroperoxy Cyclophosphamide-d4

4-Hydroperoxy Cyclophosphamide-d4

• Product Name Alternative: NIK333
• CAS Number: 1246816-71-6
• UNSPSC Description: 4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
• Target Antigen: Apoptosis; DNA Alkylator/Crosslinker; Drug Metabolite; Reactive Oxygen Species
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Field of Research: Inflammation/Immunology
• Purity: 95.0
• Solubility: 10 mM in DMSO
• Smiles: N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1
• Molecular Weight: 297.11
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG
• Shipping Conditions: Dry Ice
• Storage Conditions: -80°C, stored under nitrogen
• Clinical Information: No Development Reported