Cyclophosphamide-d4

CAT: 0804-HY-17420SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17420SSize:1 mg
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Description
Cyclophosphamide-d4 is the deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant[1][2].
CAS Number
[173547-45-0]
UNSPSC
12352005
Hazard Statement
H301, H340, H350, H360
Target
DNA Alkylator/Crosslinker
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.46
Solubility
10 mM in DMSO
Smiles
ClCCN(CCCl)P1(OCC([2H])([2H])C([2H])([2H])N1)=O
Molecular Formula
C7H11D4Cl2N2O2P
Molecular Weight
265.11
Precautions
H301, H340, H350, H360
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96 (1) :1-6.|[3]Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12 (3) :167-72.|[4]Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33 (1) :53-9.|[5]Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60 (6) :1268-1279.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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