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4-Hydroperoxy cyclophosphamide

CAT: 0804-HY-117433-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117433-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS) . 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases[1][2].
CAS Number
39800-16-3
Product Name Alternative
TAK-438 (free base), TAK-438 (Standard), TAK-438 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; DNA Alkylator/Crosslinker; Drug Metabolite; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroperoxy-cyclophosphamide.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=P1(OCCC(N1)OO)N(CCCl)CCCl
Molecular Formula
C7H15Cl2N2O4P
Molecular Weight
293.08
Precautions
H315, H319, H335
References & Citations
[1]Niu HQ, et al. Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. Int Immunopharmacol. 2018 Aug;61:45-53.|[2]Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15 (2) :332-43.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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