4-Hydroperoxy cyclophosphamide

4-Hydroperoxy cyclophosphamide

• Product Name Alternative: TAK-438 (free base)
• CAS Number: 39800-16-3
• UNSPSC Description: 4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases[1][2].
• Target Antigen: Apoptosis; DNA Alkylator/Crosslinker; Drug Metabolite; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/4-hydroperoxy-cyclophosphamide.html
• Purity: 98.0
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: O=P1(OCCC(N1)OO)N(CCCl)CCCl
• Molecular Weight: 293.08
• References & Citations: [1]Niu HQ, et al. Combination of 4-hydroperoxy cyclophosphamide and methotrexate inhibits IL-6/sIL-6R-induced RANKL expression in fibroblast-like synoviocytes via suppression of the JAK2/STAT3 and p38MAPK signaling pathway. Int Immunopharmacol. 2018 Aug;61:45-53.|[2]Strauss G, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ. 2008 Feb;15(2):332-43.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported