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ML224

CAT: 0804-HY-12381-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12381-01Size:5 mg
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Description
ML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 µM. ML224 can be used in the study of Graves' disease and other thyroid disorders.
CAS Number
[1338824-21-7]
Product Name Alternative
NCGC00242364; ANTAG3
UNSPSC
12352005
Target
TSH Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ML224.html
Concentration
10mM
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(NC1=CC(C)=C(OCC2=CC(C(N3CC4=CC=CO4)NC5=C(C=CC=C5)C3=O)=CC=C2OC)C(C)=C1)=O
Molecular Formula
C31H31N3O5
Molecular Weight
525.59
References & Citations
[1]Neumann S, et al. A selective TSH receptor antagonist inhibits stimulation of thyroid function in female mice. Endocrinology. 2014 Jan;155 (1) :310-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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C04464ML224
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A21633-5ML224 5mg
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