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ML254

CAT: 0804-HY-16654-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-16654-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML254 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia[1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[1428630-86-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml254.html
Purity
97.05
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1(C)COC1)C2=NC=C(C#CC3=CC=CC(F)=C3)C=C2
Molecular Formula
C18H15FN2O2
Molecular Weight
310.32
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Turlington M, Noetzel MJ, Chun A, et al. Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs) : discovery of 5- ((3-fluorophenyl) ethynyl) -N- (3-methyloxetan-3-yl) picolinamide (ML254) . J Med Chem. 2013;56 (20) :7976-7996.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR5

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A22242-50ML254 50mg
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