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OM-153

CAT: 0013-GTR19185140-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185140-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OM-153 is a potent dual inhibitor of tankyrase 1 and 2 (IC50 = 13 nM and 2 nM, respectively) . It suppresses WNT/β-catenin signaling and cellular proliferation, making it a valuable chemical probe for studying Wnt-driven cancers in both in vitro and in vivo research models.
CAS Number
2406278-81-5
Field of Research
Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology
Smiles
CCOc1ccc (nc1) -c1nnc ([C@H]2C[C@@H] (C2) NC (=O) c2cccc3nccnc23) n1-c1ccccc1F
Molecular Formula
C28H24FN7O2
Molecular Weight
509.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide
CAS Number2406278-81-5
PubChem CID146282356
IUPAC NameN-[3-[5-(5-ethoxy-2-pyridinyl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide
Molecular FormulaC28H24FN7O2
Molecular Weight509.5
XLogP3.1
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count38
Formal Charge0
Complexity801
SMILES
CCOC1=CN=C(C=C1)C2=NN=C(N2C3=CC=CC=C3F)C4CC(C4)NC(=O)C5=C6C(=CC=C5)N=CC=N6
InChI
InChI=1S/C28H24FN7O2/c1-2-38-19-10-11-23(32-16-19)27-35-34-26(36(27)24-9-4-3-7-21(24)29)17-14-18(15-17)33-28(37)20-6-5-8-22-25(20)31-13-12-30-22/h3-13,16-18H,2,14-15H2,1H3,(H,33,37)
InChIKey
ARCOJIXZDJYBCH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]quinoxaline-5-carboxamide
CAS: 2406278-81-5
CID: 146282356
Formula: C28H24FN7O2
MW: 509.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight509.5
XLogP33.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass509.19755120
Monoisotopic Mass509.19755120
Topological Polar Surface Area108 Ų
Heavy Atom Count38
Formal Charge0
Complexity801
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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