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EIF4A3-IN-6

CAT: 0013-GTR19185689-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185689-02Size:50 mg
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Description
EIF4A3-IN-6 is a potent small molecule inhibitor targeting the eIF4A family of RNA helicases. It serves as a valuable research tool for investigating eIF4A-dependent oncogenic translation in cancer biology, with applications in both in vitro and in vivo experimental models.
CAS Number
2100133-77-3
Field of Research
Cell Biology
Smiles
O[C@]12[C@] ([C@@H] ([C@@H] (CN) [C@H]1O) C3=CC=CC=C3) (OC=4C2=C (OC) N=C (OC) C4) C5=CC=C (C#N) C=C5
Molecular Formula
C26H25N3O5
Molecular Weight
459.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

eIF4A3-IN-6
CAS Number2100133-77-3
PubChem CID162641727
IUPAC Name4-[(2S,3R,4S,5S,6R)-4-(aminomethyl)-2,3-dihydroxy-10,12-dimethoxy-5-phenyl-7-oxa-11-azatricyclo[6.4.0.02,6]dodeca-1(12),8,10-trien-6-yl]benzonitrile
Molecular FormulaC26H25N3O5
Molecular Weight459.5
XLogP2
Topological Polar Surface Area131
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity776
SMILES
COC1=NC(=C2C(=C1)O[C@@]3([C@]2([C@@H]([C@@H]([C@H]3C4=CC=CC=C4)CN)O)O)C5=CC=C(C=C5)C#N)OC
InChI
InChI=1S/C26H25N3O5/c1-32-20-12-19-22(24(29-20)33-2)25(31)23(30)18(14-28)21(16-6-4-3-5-7-16)26(25,34-19)17-10-8-15(13-27)9-11-17/h3-12,18,21,23,30-31H,14,28H2,1-2H3/t18-,21-,23-,25+,26+/m1/s1
InChIKey
FDBZORUICONATJ-IIYLQZBSSA-N
Chemical Structure
2D Structure
2D structure of eIF4A3-IN-6
CAS: 2100133-77-3
CID: 162641727
Formula: C26H25N3O5
MW: 459.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight459.5
XLogP32
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass459.17942091
Monoisotopic Mass459.17942091
Topological Polar Surface Area131 Ų
Heavy Atom Count34
Formal Charge0
Complexity776
Isotope Atom Count0
Defined Atom Stereocenter Count5
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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