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VEGFR-2-IN-28

CAT: 0013-GTR19184812-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184812-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR-2-IN-28 is a potent small molecule inhibitor of VEGFR-2 kinase with an IC50 of 0.83 μM. It demonstrates pro-apoptotic activity and antitumor efficacy, making it a useful research tool for studying angiogenesis and oncology in both cellular and animal models.
CAS Number
2447597-39-7
Field of Research
Cardiovascular Research, Cardiovascular Research; Cell Biology, Cell Biology, Signal Transduction
Smiles
C (C=1C (=NN (C1) C2=CC=CC=C2) C3=CC (N (=O) =O) =CC=C3) =C4C (=O) N (N=C4C) C5=C (N (=O) =O) C=C (N (=O) =O) C=C5
Molecular Formula
C26H17N7O7
Molecular Weight
539.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Vegfr-2-IN-28
CAS Number2447597-39-7
PubChem CID164517144
IUPAC Name(4E)-2-(2,4-dinitrophenyl)-5-methyl-4-[[3-(3-nitrophenyl)-1-phenylpyrazol-4-yl]methylidene]pyrazol-3-one
Molecular FormulaC26H17N7O7
Molecular Weight539.5
XLogP4.5
Topological Polar Surface Area188
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Heavy Atom Count40
Formal Charge0
Complexity1070
SMILES
CC\1=NN(C(=O)/C1=C/C2=CN(N=C2C3=CC(=CC=C3)[N+](=O)[O-])C4=CC=CC=C4)C5=C(C=C(C=C5)[N+](=O)[O-])[N+](=O)[O-]
InChI
InChI=1S/C26H17N7O7/c1-16-22(26(34)30(27-16)23-11-10-21(32(37)38)14-24(23)33(39)40)13-18-15-29(19-7-3-2-4-8-19)28-25(18)17-6-5-9-20(12-17)31(35)36/h2-15H,1H3/b22-13+
InChIKey
PHOMMXJDCXTWKV-LPYMAVHISA-N
Chemical Structure
2D Structure
2D structure of Vegfr-2-IN-28
CAS: 2447597-39-7
CID: 164517144
Formula: C26H17N7O7
MW: 539.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight539.5
XLogP34.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count9
Rotatable Bond Count4
Exact Mass539.11894591
Monoisotopic Mass539.11894591
Topological Polar Surface Area188 Ų
Heavy Atom Count40
Formal Charge0
Complexity1070
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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T63804-01VEGFR-2-IN-28
MBS668224-01VEGFR-2
BA9056-25VEGFR-2-IN-29
HY-173365VEGFR-2-IN-67
HY-18625-01VEGFR-2-IN-5
HY-161855VEGFR-2-IN-50
HY-168126VEGFR-2-IN-56
HY-144796VEGFR-2-IN-15
HY-151969VEGFR-2-IN-30
HY-179046VEGFR-2-IN-78

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