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JP-153

CAT: 0013-GTR19178360Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178360Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
CAS Number
1802937-26-3
Purity
>98%
Smiles
O1C (C2=CC (OC) =C (OC) C (OC) =C2) C2=CC=C3C (=C2NC1=O) C=CC=C3
Molecular Formula
C21H19NO5
Molecular Weight
365.385
Notes
For research use only.

Chemical Information

4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS Number1802937-26-3
PubChem CID91827392
IUPAC Name4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
Molecular FormulaC21H19NO5
Molecular Weight365.4
XLogP3.9
Topological Polar Surface Area66
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity515
SMILES
COC1=CC(=CC(=C1OC)OC)C2C3=C(C4=CC=CC=C4C=C3)NC(=O)O2
InChI
InChI=1S/C21H19NO5/c1-24-16-10-13(11-17(25-2)20(16)26-3)19-15-9-8-12-6-4-5-7-14(12)18(15)22-21(23)27-19/h4-11,19H,1-3H3,(H,22,23)
InChIKey
NIDMIFDHMDRHLS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS: 1802937-26-3
CID: 91827392
Formula: C21H19NO5
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass365.12632271
Monoisotopic Mass365.12632271
Topological Polar Surface Area66 Ų
Heavy Atom Count27
Formal Charge0
Complexity515
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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