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GNF-5

CAT: 0013-GTR19178064-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19178064-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNF-5 is a non-ATP competitive Bcr-Abl inhibitor with an IC50 of 0.22 μM against wild-type Abl. As a pharmacokinetically improved analog of GNF-2, it is a valuable chemical probe for studying kinase-independent oncogenic signaling in chronic myeloid leukemia research, both in vitro and in vivo.
CAS Number
778277-15-9
Product Name Alternative
Chronic myelogenous leukemia (CML), Bcr-Abl, BcrAbl, cancer, GNF5, GNF-5, GNF 5, GNF-2, Inhibitor, inhibit, pharmacokinetic, SARSCoV, SARS-CoV
Field of Research
Cardiovascular Research, Infectious Disease & Virology, Signal Transduction
Purity
98.00% (May vary between batches)
Solubility
Ethanol:16 mg/mL (38.24 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.78 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:16.67 mg/mL (39.85 mM)
Smiles
N (C1=CC (=NC=N1) C2=CC (C (NCCO) =O) =CC=C2) C3=CC=C (OC (F) (F) F) C=C3
Molecular Formula
C20H17F3N4O3
Molecular Weight
418.37
Storage Conditions
-20°C
Notes
For research use only.

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