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GNF-6

CAT: 0013-GTR19235314-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19235314-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNF-6 (Compound 14) is an ATP-competitive inhibitor effective against BCR-ABL and its gatekeeper T315I mutant, with IC50 values ranging from 0.09 to 0.59 μM. It stabilizes the inactive DFG-out conformation by disrupting the hydrophobic spine, making it a valuable chemical probe for studying kinase resistance mechanisms in chronic myeloid leukemia research.
CAS Number
839708-29-1
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
O=C1N (CC=2C (N1C) =NC (N) =NC2) C3=CC (NC (=O) C4=CC (C (F) (F) F) =CC=C4) =CC=C3C
Molecular Formula
C22H19F3N6O2
Molecular Weight
456.42
Storage Conditions
-20°C
Notes
For research use only.

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