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SCH-1473759

CAT: 0804-HY-10482-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10482-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SCH-1473759 is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
CAS Number
1094069-99-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SCH-1473759.html
Purity
98.20
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CC1=CN2C(C(NC3=CC(CN(C(C)(CO)C)CC)=NS3)=N1)=NC=C2C4=CNN=C4
Molecular Formula
C20H26N8OS
Molecular Weight
426.54
Precautions
H302, H315, H319, H335
References & Citations
[1]Yu T, et al. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett. 2010 Jun 7;1 (5) :214-8.|[2]Basso AD, et al. SCH 1473759, a novel Aurora inhibitor, demonstrates enhanced anti-tumor activity in combination with taxanes and KSP inhibitors. Cancer Chemother Pharmacol. 2011 Oct;68 (4) :923-33.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B

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