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Cav 2.2 blocker 1

CAT: 0013-GTR19176917-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176917-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This small molecule is a potent and selective blocker of the N-type voltage-gated calcium channel Cav2.2 (IC50 = 1 nM) . It is a valuable research tool for investigating pain pathways and has demonstrated analgesic efficacy in preclinical in vivo models of neuropathic and inflammatory pain.
CAS Number
1567335-29-8
Product Name Alternative
CalciumChannel, Cav 2.2, Cav 2.2 blocker 1, Calcium Channel, Ca channels, Ca2+ channels, inhibit, Inhibitor
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.38% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.71 mM) ; DMSO:20 mg/mL (47.06 mM)
Smiles
COc1ccccc1-n1nc (cc1-c1ccc (Cl) cc1) C1CC (C) (C) OC (C) (C) C1
Molecular Formula
C25H29ClN2O2
Molecular Weight
424.96
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cav 2.2 blocker 1
CAS Number1567335-29-8
PubChem CID73292924
IUPAC Name5-(4-chlorophenyl)-1-(2-methoxyphenyl)-3-(2,2,6,6-tetramethyloxan-4-yl)pyrazole
Molecular FormulaC25H29ClN2O2
Molecular Weight425.0
XLogP5.8
Topological Polar Surface Area36.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count30
Formal Charge0
Complexity559
SMILES
CC1(CC(CC(O1)(C)C)C2=NN(C(=C2)C3=CC=C(C=C3)Cl)C4=CC=CC=C4OC)C
InChI
InChI=1S/C25H29ClN2O2/c1-24(2)15-18(16-25(3,4)30-24)20-14-22(17-10-12-19(26)13-11-17)28(27-20)21-8-6-7-9-23(21)29-5/h6-14,18H,15-16H2,1-5H3
InChIKey
LDURKOGJFOYENC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cav 2.2 blocker 1
CAS: 1567335-29-8
CID: 73292924
Formula: C25H29ClN2O2
MW: 425.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight425.0
XLogP35.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass424.1917559
Monoisotopic Mass424.1917559
Topological Polar Surface Area36.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity559
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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