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Mitotane

CAT: 0013-GTR19176671-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19176671-01Size:50 mg
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Description
Mitotane is an adrenocorticolytic agent derived from DDD, selectively targeting and inhibiting adrenal cortical cells and hormone production. It is used in research models of adrenocortical carcinoma and Cushing's syndrome, with studies demonstrating its cytotoxic effects in both in vitro and in vivo experimental settings.
CAS Number
53-19-0
Product Name Alternative
Mitotan, Mitotane, o, p'-DDD, NCI-C04933, NCI-C-04933, NCI-C 04933, Inhibitor, inhibit, H295R, HepaRG, cholesterol, drug-drug interactions, corticotroph cells, antineoplastic, Apoptosis, 2,4′-DDD, adrenocortical carcinoma, Adrenodoxin, TαT1
Field of Research
Cell Biology, Neuroscience, Pharmacology & Drug Discovery
Purity
≥95% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:60 mg/mL (187.48 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.25 mM) ; Ethanol:60 mg/mL (187.48 mM)
Smiles
ClC (Cl) C (c1ccc (Cl) cc1) c1ccccc1Cl
Molecular Formula
C14H10Cl4
Molecular Weight
320.04
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Mitotane

Mitotane is a diarylmethane.

CAS Number53-19-0
PubChem CID4211
IUPAC Name1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
Molecular FormulaC14H10Cl4
Molecular Weight320.0
XLogP6.2
Topological Polar Surface Area0
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity248
SMILES
C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChIKey
JWBOIMRXGHLCPP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mitotane
CAS: 53-19-0
CID: 4211
Formula: C14H10Cl4
MW: 320.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.0
XLogP36.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Exact Mass319.950711
Monoisotopic Mass317.953661
Topological Polar Surface Area0 Ų
Heavy Atom Count18
Formal Charge0
Complexity248
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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