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Mitotan

CAT: 0013-GTR19162123-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162123-01Size:1 g
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Description
Mitotane (2,4′-DDD), an isomer of DDD and derivative of DDT, is an antineoplastic medication used in the treatment of adrenocortical carcinoma. (In Vitro) :Mitotane (1 nM-100 μM; 6 days) significantly reduces H295R cell proliferation.Mitotane (10-100 μM; 6 or 48 h; TαT1 cells) reduces TαT1 cell viability in time- and dose-dependent manners; significantly and dose dependently increases caspase 3/7 activity from 60 μM to 80 μM; induced a significant and dose-dependent reduction in TSH secretion and TSH β-subunit mRNA expression from 40 μM to 100 μM.Mitotane (1-30 μM; 24 h; HepG2) increases transcription of the CYP3A4 and CYP2B6 gene in a dose-dependent manner.Mitotane (20 and 40 μM; 6 h) significantly reduces the number of neutral lipid droplets per cell in HepaRG, also induces a significant decrease in triacylglycerol-labeled lipid droplets; decreases the expression levels of PLIN1 and PLIN3. (In Vivo) :Mitotane (440 mg/kg; i.p. or p.o, ; 5 days a week, for 7 weeks) significantly reduces the volume of xenografts at an early time point after H295R cells inoculation.
CAS Number
53-19-0
Product Name Alternative
O, p'-DDD | NSC 38721
Purity
>98% (HPLC)
Solubility
Ethanol: 64 mg/mL warmed (199.97 mM) ; DMSO: 64 mg/mL (199.97 mM)
Smiles
ClC1=CC=C (C (C2=CC=CC=C2Cl) C (Cl) Cl) C=C1
Molecular Formula
C14H10Cl4
Molecular Weight
320.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-chloro-2- (2,2-dichloro-1- (4-chlorophenyl) ethyl) benzene

Chemical Information

Mitotane

Mitotane is a diarylmethane.

CAS Number53-19-0
PubChem CID4211
IUPAC Name1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene
Molecular FormulaC14H10Cl4
Molecular Weight320.0
XLogP6.2
Topological Polar Surface Area0
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Heavy Atom Count18
Formal Charge0
Complexity248
SMILES
C1=CC=C(C(=C1)C(C2=CC=C(C=C2)Cl)C(Cl)Cl)Cl
InChI
InChI=1S/C14H10Cl4/c15-10-7-5-9(6-8-10)13(14(17)18)11-3-1-2-4-12(11)16/h1-8,13-14H
InChIKey
JWBOIMRXGHLCPP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mitotane
CAS: 53-19-0
CID: 4211
Formula: C14H10Cl4
MW: 320.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight320.0
XLogP36.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Exact Mass319.950711
Monoisotopic Mass317.953661
Topological Polar Surface Area0 Ų
Heavy Atom Count18
Formal Charge0
Complexity248
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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