HPN-01

CAT: 0804-HY-135366-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-135366-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

HPN-01 is a potent and selective IKK inhibitor, with pIC50 values of 6.4, 7.0 and [1].

CAS Number

928655-63-4

UNSPSC

12352005

Target

IKK

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hpn-01.html

Purity

98.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=C(N)C(C2=CC=C(S(=O)(N)=O)C=C2)=CC(C3=CC=C(Cl)C=C3)=C1)N

Molecular Formula

C19H16ClN3O3S

Molecular Weight

401.87

References & Citations

[1]Christopher JA, et al. The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-alpha and IKK-beta kinases. Bioorg Med Chem Lett. 2007 Jul 15;17 (14) :3972-7.|[2]Ke Li, et al. Amino-aryl-benzamide compounds and methods of use thereof.WO2018204775A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

IKK-α; IKK-β; IKKε

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