Products for Research Use Only
RegisterLogin

AZD4320

CAT: 0013-GTR19175191-06Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19175191-06Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD4320 is a dual BCL-2/BCL-xL inhibitor with reported IC50 values of 26 nM (KPUM-MS3), 17 nM (KPUM-UH1), and 170 nM (STR-428) in cellular assays. This small molecule is a research tool for studying apoptosis mechanisms and has been utilized in preclinical in vitro cancer models.
CAS Number
1357576-48-7
Product Name Alternative
AZD4320, AZD-4320, AZD 4320, BCL-2, BCL2, Bcl-2 Family, BCLxL, BCL-xL, Inhibitor, inhibit
Field of Research
Cell Biology
Purity
98.13% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (5.29 mM) ; DMSO:125 mg/mL (132.2 mM)
Smiles
CN (CCO) CC[C@H] (CSc1ccccc1) Nc1ccc (cc1S (=O) (=O) C (F) (F) F) S (=O) (=O) NC (=O) c1ccc (cc1) N1CCC (CC1) [C@@H] (O) c1ccccc1-c1ccc (Cl) cc1
Molecular Formula
C45H48ClF3N4O7S3
Molecular Weight
945.53
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Azd-4320

dual inhibitor of Bcl-2 and Bcl-x L

CAS Number1357576-48-7
PubChem CID86661883
IUPAC Name4-[4-[(R)-[2-(4-chlorophenyl)phenyl]-hydroxymethyl]piperidin-1-yl]-N-[4-[[(2R)-4-[2-hydroxyethyl(methyl)amino]-1-phenylsulfanylbutan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonylbenzamide
Molecular FormulaC45H48ClF3N4O7S3
Molecular Weight945.5
XLogP9.3
Topological Polar Surface Area198
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count18
Heavy Atom Count63
Formal Charge0
Complexity1630
SMILES
CN(CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCC(CC4)[C@H](C5=CC=CC=C5C6=CC=C(C=C6)Cl)O)S(=O)(=O)C(F)(F)F)CCO
InChI
InChI=1S/C45H48ClF3N4O7S3/c1-52(27-28-54)24-23-35(30-61-37-7-3-2-4-8-37)50-41-20-19-38(29-42(41)62(57,58)45(47,48)49)63(59,60)51-44(56)33-13-17-36(18-14-33)53-25-21-32(22-26-53)43(55)40-10-6-5-9-39(40)31-11-15-34(46)16-12-31/h2-20,29,32,35,43,50,54-55H,21-28,30H2,1H3,(H,51,56)/t35-,43-/m1/s1
InChIKey
UNEJSHNDABUZNY-UJNHCCGESA-N
Chemical Structure
2D Structure
2D structure of Azd-4320
CAS: 1357576-48-7
CID: 86661883
Formula: C45H48ClF3N4O7S3
MW: 945.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight945.5
XLogP39.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count18
Exact Mass944.2325756
Monoisotopic Mass944.2325756
Topological Polar Surface Area198 Ų
Heavy Atom Count63
Formal Charge0
Complexity1630
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19213350AZD4625
GTR19185424AZD4625
GTR19198170-01AZD6370
GTR19162814-01AZD1390
GTR19171759-01AZD8330
GTR19167471-01AZD7325
GTR19160956-01AZD8330
GTR19168578-01Azd1390
GTR19274631-01AZD4316
GTR19203982-01AZD8329

Alternative Products

CatalogName
HY-112416-01AZD4320

Popular Products