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BNC105

CAT: 0013-GTR19175116-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19175116-01Size:1 mg
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Description
BNC105
CAS Number
945771-74-4
Product Name Alternative
BNC 105, BNC105, BNC-105, inhibit, Inhibitor, Microtubule/Tubulin, Microtubule Associated, MicrotubuleAssociated, tubulin polymerization
Field of Research
Signal Transduction
Purity
95.94% (May vary between batches)
Solubility
H2O:< 0.1 mg/mL (insoluble) ; DMSO:25 mg/mL (67.14 mM) ;10% DMSO+90% Corn Oil:2 mg/mL (5.37 mM)
Smiles
COc1ccc2c (C (=O) c3cc (OC) c (OC) c (OC) c3) c (C) oc2c1O
Molecular Formula
C20H20O7
Molecular Weight
372.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bnc-105

Vascular Disrupting Agent BNC105 is a vascular disrupting agent (VDA), with potential anti-vascular and antineoplastic activities. Upon administration, vascular disrupting agent BNC105 binds to tubulin and inhibits its polymerization, which results in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. This deprives tumor cells of nutrients and results in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization.

CAS Number945771-74-4
PubChem CID24786555
IUPAC Name(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone
Molecular FormulaC20H20O7
Molecular Weight372.4
XLogP3.6
Topological Polar Surface Area87.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity499
SMILES
CC1=C(C2=C(O1)C(=C(C=C2)OC)O)C(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI
InChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3
InChIKey
RADMJHVVIZTENA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bnc-105
CAS: 945771-74-4
CID: 24786555
Formula: C20H20O7
MW: 372.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.4
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass372.12090297
Monoisotopic Mass372.12090297
Topological Polar Surface Area87.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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