Products for Research Use Only
RegisterLogin

BNC105

CAT: 0931-T14694-08Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T14694-08Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
945771-74-4
Target
Microtubule Associated
Related Pathways
Cytoskeletal Signaling
Purity
0.9657
Bioactivity
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
Smiles
COc1ccc2c(C(=O)c3cc(OC)c(OC)c(OC)c3)c(C)oc2c1O
Molecular Formula
C20H20O7
Molecular Weight
372.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Bnc-105

Vascular Disrupting Agent BNC105 is a vascular disrupting agent (VDA), with potential anti-vascular and antineoplastic activities. Upon administration, vascular disrupting agent BNC105 binds to tubulin and inhibits its polymerization, which results in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. This deprives tumor cells of nutrients and results in tumor cell apoptosis. In addition to its VDA activity, this agent has a direct cytotoxic effect on tumor cells by inhibiting tubulin polymerization.

CAS Number945771-74-4
PubChem CID24786555
IUPAC Name(7-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)-(3,4,5-trimethoxyphenyl)methanone
Molecular FormulaC20H20O7
Molecular Weight372.4
XLogP3.6
Topological Polar Surface Area87.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity499
SMILES
CC1=C(C2=C(O1)C(=C(C=C2)OC)O)C(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI
InChI=1S/C20H20O7/c1-10-16(12-6-7-13(23-2)18(22)19(12)27-10)17(21)11-8-14(24-3)20(26-5)15(9-11)25-4/h6-9,22H,1-5H3
InChIKey
RADMJHVVIZTENA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bnc-105
CAS: 945771-74-4
CID: 24786555
Formula: C20H20O7
MW: 372.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.4
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass372.12090297
Monoisotopic Mass372.12090297
Topological Polar Surface Area87.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
T68273-01BNC105P
T8318-01BNC210
T14695-01BNC375
TMAB-03175-01Anti-BNC1 Polyclonal Antibody
TMAB-03174-01Anti-BNC1 Polyclonal Antibody 2

Alternative Products

CatalogName
MBS3614595-01BNC105
A20945-200BNC105 200mg
A20945-25BNC105 25mg
A20945-5BNC105 5mg
A20945-1BNC105 1mg
A20945-100BNC105 100mg
A20945-50BNC105 50mg
A20945-10BNC105 10mg
A20945-10mM-DBNC105 10mM * 1mL in DMSO

Popular Products