HDAC6-IN-41

CAT: 0804-HY-158308Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-158308Size:1 Each
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Description
HDAC6-IN-41 (Compound E24) is a selective inhibitor for histone deacetylase 6 (HDAC6), with IC50 of 14 and 422 nM, for HDAC6 and HDAC8, respectively. HDAC6-IN-41 upregulates the acetylation of α-tubulin and histone site SMC3[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-41.html
Solubility
10 mM in DMSO
Smiles
O=S(OC1=CC=C2C=CC=CC2=C1)(OC3=CC(C(NO)=O)=CN=C3)=O
Molecular Formula
C16H12N2O6S
Molecular Weight
360.34
References & Citations
[1]Hansen T N, et al., Sulfur (VI) Fluoride Exchange Chemistry in Solid-Phase Synthesis of Compound Arrays: Discovery of Histone Deacetylase Inhibitors[J]. JACS Au, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC6; HDAC8

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